The impact of administering vitamin D supplements on handgrip strength and performance in the timed-up-and-go test in frail elderly individuals: A meta-analysis involving randomized controlled trials

Erdilian Pratama; Chrisandi Rizqiansyah; Wahyu Firmansah; Sri Soenarti

doi:10.69863/dim.v1i1.3

Authors

Erdilian Pratama Department of Internal Medicine, Universitas Brawijaya, Malang, Indonesia
Chrisandi Rizqiansyah Department of Internal Medicine, Universitas Brawijaya, Malang, Indonesia
Wahyu Firmansah Department of Internal Medicine, Universitas Brawijaya, Malang, Indonesia
Sri Soenarti Division of Geriatric and Gerontology, Department of Internal Medicine, Universitas Brawijaya, Malang, Indonesia

DOI:

https://doi.org/10.69863/dim.v1i1.3

Keywords:

vitamin D, frailty, timed-up-and-go test, handgrip strength

Abstract

BACKGROUND: Ongoing debates continue regarding the specific effects of vitamin D intake on the timed-up-and-go test and handgrip strength.

OBJECTIVES: To assess the impact of vitamin D supplementation on handgrip strength and performance in the timed-up-and-go test.

METHODS: Between May and June of 2023, a systematic review and meta-analysis were undertaken to assess the effects of vitamin D intake on handgrip strength and performance in the timed-up-and-go test. A comprehensive search was performed on Google Scholar, Web of Science, and PubMed to search for relevant articles published until June 2023. The analysis exclusively incorporated randomized controlled trials (RCTs) available in English publications, with a specific emphasis on evaluating the impact of vitamin D supplementation on both handgrip strength and performance in the timed-up-and-go test. Inverse variant meta-analysis was employed to evaluate the impact of vitamin D intake on the timed-up-and-go test and handgrip strength.

RESULTS: A total of 21 appropriate studies were incorporated into the systematic review. Our findings revealed a favorable impact of vitamin D administration on enhancing performance in the timed-up-and-go test. Conversely, we could not ascertain any advantageous effects of vitamin D intake on handgrip strength. Despite the notable enhancement observed in the timed-up-and-go test, our analysis did not yield statistically significant evidence supporting the impact of vitamin D intake on handgrip strength based on the included studies.

CONCLUSION: Our study findings reveal that vitamin D is an essential component in improving the timed-up-and-go test.

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References

Koller K, Rockwood K. Frailty in older adults: implications for end-of-life care. Cleve Clin J Med 2013;80(3):168-174.doi: 10.3949/ccjm.80a.12100. PMID: 23456467

Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56(3):M146-M156.doi: 10.1093/gerona/56.3.m146. PMID: 11253156

Topinkova E. Aging, disability and frailty. Ann Nutr Metab 2008;52(1):6-11.doi: 10.1159/000115340. PMID: 18382070

Roubenoff R. Sarcopenia and its implications for the elderly. Eur J Clin Nutr 2000;54(3):S40-S47.doi: 10.1038/sj.ejcn.1601024. PMID: 11041074

Remelli F, Vitali A, Zurlo A, et al. Vitamin D deficiency and sarcopenia in older persons. Nutrients 2019;11(12):2861.doi: 10.3390/nu11122861. PMID: 31766576

Yanai H. Nutrition for sarcopenia. J Clin Med Res 2015;7(12):926-931.doi: 10.14740/jocmr2361w. PMID: 26566405

Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev 2021;10(1):89.doi: 10.1186/s13643-021-01626-4. PMID: 33781348

Mohsina S, Gurushankari B, Niranjan R, et al. Assessment of the quality of randomized controlled trials in surgery using Jadad score: Where do we stand? J Postgrad Med 2022;68(4):207-212.doi: 10.4103/jpgm.JPGM_104_21. PMID: 35417999

Bauer JM, Verlaan S, Bautmans I, et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 2015;16(9):740-747.doi: 10.1016/j.jamda.2015.05.021. PMID: 26170041

Verreijen AM, Verlaan S, Engberink MF, et al. A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial. Am J Clin Nutr 2015;101(2):279-286.doi: 10.3945/ajcn.114.090290. PMID: 25646324

Glendenning P, Zhu K, Inderjeeth C, et al. Effects of three-monthly oral 150,000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: a randomized controlled trial. J Bone Miner Res 2012;27(1):170-176.doi: 10.1002/jbmr.524. PMID: 21956713

De Luis DA, Izaola O, Bachiller P, et al. Effect on quality of life and handgrip strength by dynamometry of an enteral specific suplements with beta-hydroxy-beta-methylbutyrate and vitamin d in elderly patients. Nutr Hosp 2015;32(1):202-207.doi: 10.3305/nh.2015.32.1.9083. PMID: 26262718

Takeuchi I, Yoshimura Y, Shimazu S, et al. Effects of branched-chain amino acids and vitamin D supplementation on physical function, muscle mass and strength, and nutritional status in sarcopenic older adults undergoing hospital-based rehabilitation: A multicenter randomized controlled trial. Geriatr Gerontol Int 2019;19(1):12-17.doi: 10.1111/ggi.13547. PMID: 30358032

Imaoka M, Higuchi Y, Todo E, et al. Low-frequency exercise and vitamin d supplementation reduce falls among institutionalized frail elderly. International Journal of Gerontology 2016;10(4):202-206.doi. PMID:

Kim H, Kim M, Kojima N, et al. Exercise and nutritional supplementation on community-dwelling elderly japanese women with sarcopenic obesity: A randomized controlled trial. J Am Med Dir Assoc 2016;17(11):1011-1019.doi: 10.1016/j.jamda.2016.06.016. PMID: 27544583

El Hajj C, Fares S, Chardigny JM, et al. Vitamin D supplementation and muscle strength in pre-sarcopenic elderly Lebanese people: a randomized controlled trial. Arch Osteoporos 2018;14(1):4.doi: 10.1007/s11657-018-0553-2. PMID: 30569340

Bo Y, Liu C, Ji Z, et al. A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial. Clin Nutr 2019;38(1):159-164.doi: 10.1016/j.clnu.2017.12.020. PMID: 29395372

Cangussu LM, Nahas-Neto J, Orsatti CL, et al. Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial. Osteoporos Int 2015;26(10):2413-2421.doi: 10.1007/s00198-015-3151-9. PMID: 25956283

Lin CC, Shih MH, Chen CD, et al. Effects of adequate dietary protein with whey protein, leucine, and vitamin D supplementation on sarcopenia in older adults: An open-label, parallel-group study. Clin Nutr 2021;40(3):1323-1329.doi: 10.1016/j.clnu.2020.08.017. PMID: 32928579

Rondanelli M, Klersy C, Terracol G, et al. Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly. Am J Clin Nutr 2016;103(3):830-840.doi: 10.3945/ajcn.115.113357. PMID: 26864356

Bunout D, Barrera G, Leiva L, et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontol 2006;41(8):746-752.doi: 10.1016/j.exger.2006.05.001. PMID: 16797903

Zhu K, Austin N, Devine A, et al. A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. J Am Geriatr Soc 2010;58(11):2063-2068.doi: 10.1111/j.1532-5415.2010.03142.x. PMID: 21054285

Sakalli H, Arslan D, Yucel AE. The effect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study. Rheumatol Int 2012;32(8):2279-2283.doi: 10.1007/s00296-011-1943-6. PMID: 21556746

Pfeifer M, Begerow B, Minne HW, et al. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 2009;20(2):315-322.doi: 10.1007/s00198-008-0662-7. PMID: 18629569

Janssen HC, Samson MM, Verhaar HJ. Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation. Aging Clin Exp Res 2010;22(1):78-84.doi: 10.1007/BF03324819. PMID: 20305368

Rosendahl-Riise H, Spielau U, Ranhoff AH, et al. Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and meta-analysis. J Hum Nutr Diet 2017;30(1):3-15.doi: 10.1111/jhn.12394. PMID: 27460044

Abshirini M, Mozaffari H, Kord-Varkaneh H, et al. The effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials. J Hum Nutr Diet 2020;33(2):207-221.doi: 10.1111/jhn.12717. PMID: 31729817

Olsson K, Saini A, Stromberg A, et al. Evidence for vitamin D receptor expression and direct effects of 1alpha,25(oh)2d3 in human skeletal muscle precursor cells. Endocrinology 2016;157(1):98-111.doi: 10.1210/en.2015-1685. PMID: 26469137

Bischoff HA, Borchers M, Gudat F, et al. In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 2001;33(1):19-24.doi: 10.1023/a:1017535728844. PMID: 11352397

Hassan-Smith ZK, Jenkinson C, Smith DJ, et al. 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression. PLoS One 2017;12(2):e0170665.doi: 10.1371/journal.pone.0170665. PMID: 28199350

Latham NK, Anderson CS, Lee A, et al. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). J Am Geriatr Soc 2003;51(3):291-299.doi: 10.1046/j.1532-5415.2003.51101.x. PMID: 12588571